Which of the following is the correct mechanism of action of cyclosporine?
Cyclosporine is an immunosuppressant that inhibits calcineurin by binding to cyclophilin.
Cyclosproine, tacrolimus, and pimecrolimus are all calcineurin inhibitors. Calcineurin is a phosphatase that is activated when in the presence of calmodulin and calcium that is necessary for cytokine synthesis within T cells. It does so by dephosphorylating nuclear factor of activated T-cells, cytoplasmic 1 (NFAT-1). Ultimately, inhibiting calcineurin prevents interleukin-2 (IL-2) production, which decreases the release of histamine and inflammatory cytokines and prevents T cell proliferation.
As noted above, cyclosproine, tacrolimus, and pimecrolimus are all calcineurin inhibitors, however, their associated mechanisms of action differ:
In addition to its use as an anti-rejection agent in organ transplantation, cyclosporine is also not infrequently utilized in dermatology. Its uses include but are not limited to the following dermatologic disorders: